MECHANISM OF ACTION
5-Amino-1MQ is not a peptide, it's a small molecule that blocks a specific enzyme called NNMT (nicotinamide N-methyltransferase). This enzyme is very active in fat tissue and plays a role in making fat cells larger and more numerous. When you block it, fat cells shrink and the body produces more NAD+ (a key energy-carrying molecule used by every cell). NAD+ is important for energy production, DNA repair, and ageing, raising it has been a major focus of longevity research. The same enzyme is also found in brain areas that handle dopamine, which is why 5-Amino-1MQ is also studied for cognitive applications.
RESEARCH APPLICATIONS
- Adipose NNMT inhibition and fat mass reduction
- NAD+ pathway upregulation (indirect, via NNMT blockade)
- Cognitive and dopaminergic metabolism research
- Metabolic syndrome models
- Adipose tissue remodelling research protocols
RESEARCH HIGHLIGHTS
Fat Cell Reduction via NNMT Inhibition
2019Preclinical research showed 5A1MQ treatment reduced fat cell size, weight gain, and adipose tissue mass on high-fat diet without systemic toxicity.
Ref: Neelakantan et al., JACS
SAM and NAD+ Axis
2013NNMT inhibition increased intracellular SAM and NAD+ levels, activating SIRT1 and PGC-1α - metabolic regulators relevant to longevity and energy metabolism.
Ref: Ulanovskaya et al., Nature Chem Biol
RESEARCH PROTOCOL NOTES
Chemical Identity
Storage & Stability
Store at 2–8°C. Small molecule - more stable than peptides. Protect from moisture and light.
Regulatory Status
Research compound. No regulatory approval. Not on WADA prohibited list. SAHPRA: unscheduled research compound.