Research Compendium/CJC-1295
Growth Hormone AxisResearch OnlyNot For Human Consumption

CJC-1295

DAC:GRF · Drug Affinity Complex: Growth Hormone Releasing Factor

A long-acting growth hormone releaser, one injection keeps your pituitary gland producing growth hormone for up to a week.

MECHANISM OF ACTION

CJC-1295 is a modified version of the signal your brain normally sends to the pituitary gland (a pea-sized gland at the base of the brain) telling it to release growth hormone. The natural signal only lasts about 30 minutes before it breaks down. CJC-1295 is engineered to grab onto albumin (a common protein in your blood) once injected, which protects it from breaking down. This extends its activity from 30 minutes to roughly 6–8 days per injection. Your pituitary then releases growth hormone in pulses, the same natural pattern, raising both growth hormone and IGF-1 (a growth factor that supports muscle and recovery). Unlike injecting growth hormone directly, this keeps the body's own feedback system intact.

RESEARCH APPLICATIONS

  • GH secretagogue research and pituitary axis modelling
  • Body composition - lean mass accretion and adipose reduction
  • IGF-1 axis stimulation research
  • Age-related GH decline (somatopause) models
  • Synergistic stacks with GHRP agents (Ipamorelin)

RESEARCH HIGHLIGHTS

Extended GH and IGF-1 Elevation

2006

Phase I/II trial showed single SC dose (2 mcg/kg) produced GH peak elevation lasting >6 days with proportional IGF-1 increases.

Ref: Teichman et al., JCEM

Sustained IGF-1 Response

2009

Twice-weekly administration maintained IGF-1 elevation above baseline for 14+ days with no tachyphylaxis over 6-week study periods.

Ref: Ionescu et al., Growth Horm IGF Res

RESEARCH PROTOCOL NOTES

Research doses1–2 mcg/kg or 500mcg–2mg fixed dose
CombinationStacked with Ipamorelin (GHRP) for synergistic GH pulse amplification - Growth Matrix Stack
Available formatsVial (2mg), Pen, self-mix kits (with Ipamorelin)

Chemical Identity

Molecular FormulaC165H269N47O46
Molecular Weight3647.1 g/mol
CAS Number863288-34-0
SolubilitySoluble in bacteriostatic water

Storage & Stability

Lyophilised: 2–8°C or -20°C. Reconstituted: 2–8°C, 21–28 days. Avoid room temperature.

Regulatory Status

No regulatory approval. WADA prohibited (S2). SAHPRA: import authorisation required for research.

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