MECHANISM OF ACTION
Gonadorelin is a synthetic copy of a natural brain signal (GnRH, gonadotropin-releasing hormone) that your hypothalamus normally sends in regular pulses to the pituitary gland. Those pulses tell the pituitary to release LH and FSH, hormones that travel to the testes and tell them to produce testosterone and sperm. The critical point: it only works when given in pulses. If given continuously without breaks, the pituitary gets overwhelmed and actually shuts down, the opposite of what you want. When men use testosterone therapy, their brain naturally stops sending GnRH signals (because it detects enough testosterone already), which can cause the testes to shrink and sperm production to stop. Pulsatile gonadorelin keeps the testes receiving their activation signal, preserving their function.
RESEARCH APPLICATIONS
- Testicular function preservation during androgen therapy
- HPG axis restoration research
- Spermatogenesis support models
- Hypogonadotropic hypogonadism research
- Pulsatile GnRH receptor pharmacology
RESEARCH HIGHLIGHTS
Testicular Volume Preservation
2006Pulsatile gonadorelin during TRT prevented the testicular atrophy seen with exogenous testosterone alone, maintaining Sertoli cell function and spermatogenesis in most subjects.
Ref: Liu et al., JCEM
RESEARCH PROTOCOL NOTES
Chemical Identity
Sequence
pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
Storage & Stability
Lyophilised: -20°C. Reconstituted: 2–8°C, 7–14 days. Very short plasma half-life makes careful reconstitution timing important.
Regulatory Status
Approved as Factrel (Pfizer) for diagnostic use. Compounded versions used in fertility and men's health contexts. SA: Schedule 4/research compound depending on indication. WADA: prohibited under S2.