MECHANISM OF ACTION
Kisspeptin is a brain peptide that acts like the starting gun for your reproductive hormone system. It sends the signal that tells the brain to release GnRH (the hormone that then tells the pituitary gland to release LH and FSH, the hormones that control the monthly cycle and ovulation). Without enough kisspeptin signalling, the whole reproductive hormone chain breaks down. Scientists discovered its role when they found that people born with a faulty kisspeptin receptor had no puberty and could not reproduce. KP-10 is the shortest active fragment, just the 10 amino acid piece at the end of the full molecule. Research is exploring kisspeptin as a gentler, more more targeted research tool for studying the reproductive signalling axis.
RESEARCH APPLICATIONS
- GnRH pulse-generation research
- HPG axis signalling studies
- Kisspeptin neuron biology
- Reproductive neuroendocrinology research
RESEARCH HIGHLIGHTS
Upstream of GnRH
2003Landmark work identified kisspeptin signalling as required for normal GnRH pulse generation, making it a core reference molecule in reproductive neuroendocrinology. Research observations only.
Ref: Seminara et al., NEJM
Receptor characterisation
2018Laboratory studies map its action at the KISS1R receptor and the downstream LH response used in signalling research.
Ref: Reviewed in Endocr Rev
RESEARCH PROTOCOL NOTES
Chemical Identity
Storage & Stability
Lyophilised: -20°C. Reconstituted: 2–8°C, 14 days. Handle gently - fragile peptide.
Regulatory Status
Unscheduled in South Africa. Supplied for laboratory and research use only. Not a registered medicine, not evaluated by SAHPRA, not for human consumption. Not WADA prohibited.
Important - read before proceeding
This page is a summary of published scientific literature about a molecule. It is provided for research and educational purposes only. Nothing on this page is medical advice, a diagnosis, a recommendation, a prescription, or a claim that this compound treats, cures, prevents or improves any condition in humans. Research findings described here are observations reported by third-party researchers about the molecule - they are not statements about the product supplied by Bio Intelligence, and they should not be read as an expected outcome.
Compounds supplied are not registered medicines, have not been evaluated by SAHPRA, and are not for human consumption. No dosing, route of administration or usage guidance is provided by Bio Intelligence. If you have a health concern, speak to a registered healthcare practitioner.