Research Compendium/KPV
Recovery & RepairResearch OnlyNot For Human Consumption

KPV

Lys-Pro-Val · Alpha-MSH tripeptide C-terminus · KPV/KLOW Stack

A tiny three-part peptide that studied for its role in managing inflammation responses, especially in the gut, and also in skin and throughout the body.

MECHANISM OF ACTION

KPV is one of the smallest peptides studied for inflammation, just three amino acids (building blocks) linked together. It comes from a larger hormone your body already makes. Despite its tiny size, it powerfully switches off the signals that cause inflammation inside cells. What makes it interesting is that it works especially well in the gut: when taken orally, it gets absorbed directly through the intestinal lining and acts locally where it lands. KLOW is a related compound often paired with KPV to cover a broader range of inflammation pathways.

RESEARCH APPLICATIONS

  • Inflammatory bowel disease and gut mucosal repair models
  • Skin inflammation and wound recovery (topical and systemic)
  • Systemic anti-inflammatory research (NF-κB pathway)
  • Gut-brain axis inflammation modelling
  • Post-injury tissue recovery stacks (with BPC-157)

RESEARCH HIGHLIGHTS

IBD Mucosal Protection

2010

KPV incorporated into hydrogel nanoparticles delivered orally demonstrated significant reduction in colitis markers (MPO, TNF-α, IL-6) vs. controls in preclinical colitis models.

Ref: Laroui et al., Gastroenterology

NF-κB Anti-Inflammatory Mechanism

2008

KPV inhibits NF-κB nuclear translocation independently of MC1R binding, suggesting a direct intracellular anti-inflammatory mechanism distinct from α-MSH.

Ref: Brzoska et al., Peptides

RESEARCH PROTOCOL NOTES

Research concentration0.5–2 mg per administration
RouteSC injection or oral (gut-specific activity via PepT1)
Stack contextOften combined with KLOW for broader anti-inflammatory coverage
Available formatsVial, Pen (KPV/KLOW Stack)

Chemical Identity

Molecular FormulaC15H28N4O4
Molecular Weight328.4 g/mol
CAS Number63958-90-7
SolubilityHighly soluble in water

Sequence

Lys-Pro-Val

Storage & Stability

Lyophilised: -20°C. Reconstituted: 2–8°C, use within 14 days. Small tripeptide - less stable in solution than larger peptides.

Regulatory Status

Research compound. No regulatory approval. Not WADA listed. SAHPRA: unscheduled research compound.

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