MECHANISM OF ACTION
SLU-PP-332 is not a peptide, it's a small molecule that works like a key for a group of switches inside the cell nucleus called ERRs (estrogen-related receptors, named for their structure, not because they affect estrogen). These switches control genes that respond to aerobic exercise: building more mitochondria (power plants in muscle cells), burning fat for fuel, and improving oxygen use. When SLU-PP-332 activates all three ERR switches at once, it triggers the same gene activity as a long cardio session, without the physical exercise. In research animals, it increased running endurance by around 70% over four weeks. It's one of the newest compounds in the exercise-mimetic category and has no established human dose yet.
RESEARCH APPLICATIONS
- Exercise mimetic research - endurance and VO2 max modelling
- Mitochondrial biogenesis upregulation
- Fatty acid oxidation and metabolic efficiency
- Heart failure and muscle wasting models
- Combination with AMPK activators (MOTS-C)
RESEARCH HIGHLIGHTS
Endurance Enhancement
2023SLU-PP-332 (4 weeks, research-dose IP) increased running capacity by ~70% vs. controls and upregulated PGC-1α, VEGF, and oxidative metabolism genes in skeletal muscle.
Ref: Banerjee et al., J Med Chem
ERR Trifecta Agonism
2023Structural studies confirm simultaneous agonism at ERRα, β, and γ - activating a broader transcriptional programme than selective ERR agonists.
Ref: Pourcet et al., Nat Chem Biol
RESEARCH PROTOCOL NOTES
Chemical Identity
Storage & Stability
Small molecule - stable at 2–8°C. Protect from light. Less degradation-sensitive than peptides.
Regulatory Status
Very early-stage research compound. No clinical trials. Not WADA prohibited (not yet on radar). SA: unscheduled research compound.
Important - read before proceeding
This page is a summary of published scientific literature about a molecule. It is provided for research and educational purposes only. Nothing on this page is medical advice, a diagnosis, a recommendation, a prescription, or a claim that this compound treats, cures, prevents or improves any condition in humans. Research findings described here are observations reported by third-party researchers about the molecule - they are not statements about the product supplied by Bio Intelligence, and they should not be read as an expected outcome.
Compounds supplied are not registered medicines, have not been evaluated by SAHPRA, and are not for human consumption. No dosing, route of administration or usage guidance is provided by Bio Intelligence. If you have a health concern, speak to a registered healthcare practitioner.