MECHANISM OF ACTION
TB-500 is based on a small piece of a protein (Thymosin Beta-4) that your body already makes. It works mainly by helping cells move to where they are needed, like getting repair workers to the right building site. It also dials down inflammation and calls in special repair cells from the bone marrow. Research has studied it for heart muscle repair after injury, recovery the surface of the eye, skin wounds, and general tissue recovery. Unlike BPC-157, which tends to work locally, TB-500 has a wider reach across the whole body.
RESEARCH APPLICATIONS
- Skeletal muscle and connective tissue repair
- Cardiac muscle repair post-infarction (preclinical)
- Corneal and ocular surface recovery models
- Anti-inflammatory modelling (NF-κB pathway)
- Progenitor/stem cell mobilisation research
RESEARCH HIGHLIGHTS
Cardiac Progenitor Cell Activation
2011Tβ4 treatment in post-MI preclinical models stimulated cardiac progenitor cell differentiation and reduced infarct scar size vs. saline controls.
Ref: Sopko et al., J Mol Cell Cardiol
Corneal Wound Healing
2001Topical Tβ4 significantly accelerated corneal re-epithelialisation in preclinical models, with proposed mechanism via lamellipodia-forming actin remodelling.
Ref: Sosne et al., Invest Ophthalmol Vis Sci
RESEARCH PROTOCOL NOTES
Chemical Identity
Storage & Stability
Lyophilised: -20°C, 24+ months. Reconstituted: 2–8°C, use within 21 days. Greater solution stability than BPC-157.
Regulatory Status
No regulatory approval. WADA prohibited under S2 (Peptide Hormones). Research compound in South Africa.